postheadericon Frontotemporal Dementia and Pick's Disease

What is Frontotemporal Dementia?

Unlike Alzheimer's disease, which generally affects most areas of the brain, Frontotemporal Dementia is an umbrella term for a group of rare disorders that primarily affect the frontal and temporal lobes of the brain – the areas generally associated with personality and behaviour. In some cases, brain cells in these areas shrink or die. In other cases, the brain cells in these areas get larger, containing round, silver "Pick's bodies". Pick's Disease refers to a subtype of Frontotemporal Dementia that has these specific abnormalities. In Frontotemporal Dementia, the changes in the brain affect the person's ability to function. Researchers estimate that approximately 2-5% of all dementia cases are Frontotemporal Dementia.

Other names often used for Frontotemporal Dementia, in addition to Pick's Disease, include:

  • Semantic Dementia
  • Frontal Lobe Dementia
  • Primary Progressive Aphasia
  • Corticobasal Degeneration
  • Pick's Complex

How does Frontotemporal Dementia affect the person?

Since the frontal and temporal areas of the brain can be affected, early symptoms often affect either behaviour and/or speech (language).

  • Changes in behaviour may include becoming either withdrawn or disinhibited (e.g., losing the ability to restrain one's behaviour and actions). The person may lose interest in personal hygiene, become easily distracted or repeat the same action over and over again. Overeating or compulsively putting objects in the mouth may occur. Sometimes incontinence is an early symptom of the disease.
  • Problems with speech (language) can range from reduction of speech to total loss, i.e. becoming mute. Echoing what has been said by others and stuttering are common symptoms. The person may have difficulty sustaining a train of thought or maintaining a conversation for any length of time. Writing and reading are also affected.

In the early stage of Frontotemporal Dementia, behaviour changes or problems with speech (language) can appear separately. As the disease progresses, these two areas will overlap. Unlike Alzheimer's disease, a person with Frontotemporal Dementia often remains oriented to time and has preserved memory in the early stages. In the later stages of the disease, general symptoms of dementia arise, i.e. confusion and forgetfulness. Motor skills are lost and swallowing difficulties occur.

What are the risk factors for Frontotemporal Dementia?

Frontotemporal Dementia tends to occur at a younger age than Alzheimer's disease and can affect both men and women. The average length of the disease is 2-10 years. Little is known about the cause of Frontotemporal Dementia and risk factors have yet to be identified. While most cases are not inherited, there is one extremely rare type of Frontotemporal Dementia which can be passed from generation to generation.

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